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KMID : 0384119870070010009
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Korean Journal of Clinical Pathology
1987 Volume.7 No. 1 p.9 ~ p.17
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Significance of CRP, Sialic Acid and Adenosine Deaminase Assay in Patients with Ascites
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Abstract
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Laboratory analysis of the ascitic fluid is essential to find underlying diseases. But the majority of tests performed in ascitic fluid is relatively nonspecific, especially in differentiation of tuberculosis and malignancy. Recently new tests and methodolo￢gies have been developed for the rapid, adjunct diagnosis and differentiation of causative diseases in patients with ascites.
This study is designed to evaluate the clinical usefulness of CRP, sialic acid and adenosine deaminase (ADA) tests in ascitic fluid and serum for the differential diagnosis of various diseases associated with ascites. CRP, sialic acid and ADA in 89 ascitic fluids and 56 sera of 52 patients with ascites are evaluated.
The results are as follows:
1) CRP, sialic acid levels and ADA activities are higher in exudate than in transudate.
2) For the differentiation between tuberculosis and carcinoma peritonei, ADA activities of ascites or sera, ascites/serum ADA ratio and ascites/serum CRP ratio are useful. Especially in majority of tuberculosis, ADA activity of ascites is above 221U/L and in carcinoma peritonei below 221U/L.
3) Serum CRP and sialic acid concentrations are higher in hepatoma than in liver ,cirrhosis and in non-specific inflammation than in tuberculosis.
4) CRP concentration, sialic acid concentration and ADA activity in ascitic fluid are well correlated to them in serum except CRP.
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KEYWORD
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